Chelsea survived a Leicester onslaught in the second half on Saturday to claim a morale-boosting three points, despite being reduced to 10 men for a majority of the game.
Thomas Tuchel will be back on the touchline on the South Coast were he enjoyed one of his biggest wins with the Blues, running out 6-0 victors back in April over Southampton in an electric attacking display.
Raheem Sterling will be hoping to continue scoring after getting off the mark against Leicester, whilst Kalidou Koulibaly returns from suspension, whilst Conor Gallagher takes his place following his dismissal.
Southampton narrowly lost to Manchester United on Saturday but have shown quality in the early weeks of the campaign under Ralph Hasenhüttl with new young signings showing promise.
Watch & Stream Southampton vs Chelsea Premier League Live Match Below:
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